We studied 32 patients (age 58 +/- 9 years) who had been treated with a Palmaz-Schatz stent after significant dissection complicating percutaneous transluminal coronary angioplasty (PTCA). We attempted to cover the entire site of dissection with prosthesis. The presence of dissection after PTCA was associated with Thrombolysis in Myocardial Infarction grade 0 to 1 flow in 19 patients and grade 2 flow in 13. The stented arteries were: left anterior descending artery in 19 patients, right coronary artery in seven, and left circumflex artery in five. A single stent was implanted in 11 and multiple stents in 21 patients. Angiographic success was achieved in 30 patients (94%). Two patients (6%) had urgent coronary artery bypass graft surgery, two (6%) had a myocardial infarction, and one (3%) patient died. Subacute occlusion occurred in one patient (3%). Angiographic restenosis was found in three of nine patients (33%) with a single stent and 11 of 17 (65%) with multiple stents. Clinical follow-up at 11 +/- 3 months showed the necessity of coronary artery bypass graft surgery in two patients and repeat PTCA in nine (31%). We conclude that coronary stenting is an effective treatment for significant coronary dissection after PTCA with an acceptable incidence of major cardiac events at follow-up.