Cholecystokinin octapeptide decreases food intake in white-crowned sparrows

Am J Physiol. 1993 May;264(5 Pt 2):R852-6. doi: 10.1152/ajpregu.1993.264.5.R852.

Abstract

White-crowned sparrows maintained on short days (9:15-h light-dark cycle) were peripherally injected with 1.0, 4.0, and 16 micrograms/kg ip of cholecystokinin octapeptide (CCK-8). Meal size over the subsequent 30 min was significantly depressed in a dose-dependent fashion. Water intake was not affected. The anorexic effect caused by 4.0 micrograms/kg was attenuated by 100 micrograms/kg of the type-A CCK receptor antagonist MK-329 but not by 300 micrograms/kg of the type-B CCK receptor antagonist L 365,260, suggesting that CCK-induced suppression of food intake in this species is mediated by a CCK-A receptor. Administration of both CCK-A and CCK-B receptor antagonists alone resulted in no change in meal size. These experiments suggest that white-crowned sparrows, when weight stable, respond to CCK-8 in a manner comparable with several mammalian species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Benzodiazepinones / pharmacology
  • Birds / physiology*
  • Cholecystokinin / antagonists & inhibitors
  • Devazepide
  • Drinking / drug effects
  • Eating / drug effects*
  • Injections, Intraperitoneal
  • Male
  • Phenylurea Compounds*
  • Sincalide / pharmacology*

Substances

  • Benzodiazepinones
  • Phenylurea Compounds
  • L 365260
  • Cholecystokinin
  • Devazepide
  • Sincalide