Coexistence of hereditary motor and sensory neuropathy type Ia and IgM paraproteinemic neuropathy

R Gregory; P K Thomas; R H King; P L Hallam; S Malcolm; R A Hughes; A E Harding

doi:10.1002/ana.410330615

Coexistence of hereditary motor and sensory neuropathy type Ia and IgM paraproteinemic neuropathy

Ann Neurol. 1993 Jun;33(6):649-52. doi: 10.1002/ana.410330615.

Authors

R Gregory¹, P K Thomas, R H King, P L Hallam, S Malcolm, R A Hughes, A E Harding

Affiliation

¹ University Department of Clinical Neurology, Institute of Neurology, London, UK.

PMID: 8498845
DOI: 10.1002/ana.410330615

Abstract

A patient with minimal motor dysfunction dating from early childhood developed more rapidly progressive distal weakness and positive sensory symptoms due to peripheral neuropathy in the fourth decade of life. DNA analysis showed the partial duplication of chromosome 17p associated with hereditary motor and sensory neuropathy type Ia. In addition, the patient had an IgM paraproteinemia and the typical morphological features of IgM paraproteinemic neuropathy on nerve biopsy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Chromosomes, Human, Pair 17*
Hereditary Sensory and Motor Neuropathy / complications*
Hereditary Sensory and Motor Neuropathy / genetics
Hereditary Sensory and Motor Neuropathy / immunology
Histocompatibility Antigens Class II / blood*
Humans
Immunoglobulin M / blood*
Male
Microscopy, Electron
Middle Aged
Nerve Fibers, Myelinated / ultrastructure
Paraproteinemias / complications*
Paraproteinemias / genetics
Paraproteinemias / immunology
Sural Nerve / pathology
Sural Nerve / ultrastructure
Trisomy*

Substances

Histocompatibility Antigens Class II
Immunoglobulin M