Granulocyte elastase alpha 1-proteinase inhibitor complex measurement in very low birthweight infants with severe intraventricular hemorrhage

Acta Paediatr Jpn. 1993 Apr;35(2):98-100. doi: 10.1111/j.1442-200x.1993.tb03016.x.

Abstract

We investigated the relationship between the levels of granulocyte elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in plasma and severe intraventricular hemorrhage (IVH) in very low birthweight infants. The concentrations of E-alpha 1-PI and the ratio of the concentrations of E-alpha 1-PI to polymorphonuclear leucocyte counts within 24 h of birth in infants with severe IVH were significantly higher compared with those in infants without severe IVH. E-alpha 1-PI seems to be a useful indicator of IVH.

MeSH terms

  • Cerebral Hemorrhage / blood*
  • Cerebral Hemorrhage / classification
  • Cerebral Ventricles*
  • Enzyme-Linked Immunosorbent Assay
  • Evaluation Studies as Topic
  • Humans
  • Infant, Low Birth Weight*
  • Infant, Newborn
  • Leukocyte Count
  • Leukocyte Elastase*
  • Neutrophils
  • Pancreatic Elastase / analysis*
  • Predictive Value of Tests
  • Prognosis
  • Severity of Illness Index
  • alpha 1-Antitrypsin / analysis*

Substances

  • alpha 1-Antitrypsin
  • alpha 1-antitrypsin-leukocyte elastase complex
  • Pancreatic Elastase
  • Leukocyte Elastase