Abstract
Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region. Recent studies have provided new insights into how the individual genes of the cluster are regulated through development. The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Base Sequence
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Chromatin / ultrastructure
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Erythroid Precursor Cells / metabolism
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Erythropoiesis / genetics
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Gene Expression Regulation*
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Globins / biosynthesis
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Globins / genetics*
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Humans
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Mice
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Mice, Transgenic
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Molecular Sequence Data
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Recombinant Fusion Proteins / biosynthesis
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Recombinant Fusion Proteins / genetics
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Regulatory Sequences, Nucleic Acid*
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Transcription Factors / physiology
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Transcription, Genetic
Substances
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Chromatin
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Recombinant Fusion Proteins
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Transcription Factors
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Globins