Abstract
Flavone acetic acid (FAA) was administered at a dose of 4.8 g m-2 over 1 h to patients with advanced malignant disease in combination with Interleukin II. A new high performance liquid chromatography method is described to determine both the parent compound and eight drug-related products, and the conditions required to determine these components in plasma are discussed. The half-life over the first 8 h was 2.3 h, but the terminal clearance of the drug was extremely slow. Severe (WHO Grade 4) hypotension was observed in some patients. However, incidence of this did not appear to be associated with any differences in FAA plasma concentrations, nor were there differences in FAA clearance between those patients whose tumour responded to the drug combination and those who did not.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / administration & dosage
-
Antineoplastic Agents / blood*
-
Antineoplastic Agents / pharmacokinetics*
-
Antineoplastic Combined Chemotherapy Protocols / blood
-
Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Chromatography, High Pressure Liquid / methods
-
Flavonoids / administration & dosage
-
Flavonoids / blood*
-
Flavonoids / pharmacokinetics*
-
Glucuronates / blood
-
Humans
-
Infusions, Intravenous
-
Interleukin-2 / administration & dosage
-
Melanoma / blood*
-
Melanoma / drug therapy
-
Recombinant Proteins / administration & dosage
Substances
-
Antineoplastic Agents
-
Flavonoids
-
Glucuronates
-
Interleukin-2
-
Recombinant Proteins
-
flavone acetic acid