Abstract
Bac5 and Bac7 are antimicrobial peptides of bovine neutrophils that act on enteric gram-negative bacteria. We report here that these two peptides immobilize and kill Leptospira interrogans and Leptospira biflexa with MBCs of 6 to 25 micrograms/ml. Conversely, although both peptides bind to Borrelia burgdorferi, the organism is resistant to their action.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Borrelia burgdorferi Group / drug effects*
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Borrelia burgdorferi Group / metabolism
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Leptospira / drug effects*
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Leptospira / metabolism
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Microbial Sensitivity Tests
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Peptides, Cyclic / metabolism
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Peptides, Cyclic / pharmacology*
Substances
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Anti-Bacterial Agents
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Peptides, Cyclic
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bactenecin