Apolipoprotein A-I-containing lipoproteins and atherosclerosis

Curr Opin Lipidol. 1995 Oct;6(5):281-5. doi: 10.1097/00041433-199510000-00007.

Abstract

Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholesterol transport. This review describes the different apolipoprotein A-I-containing HDL subfractions, their role in reverse cholesterol transport, and their metabolic interconversions and relationship with lipoprotein-modifying enzymes.

Publication types

  • Review

MeSH terms

  • Animals
  • Apolipoprotein A-I / chemistry
  • Apolipoprotein A-I / metabolism*
  • Arteriosclerosis / genetics
  • Arteriosclerosis / metabolism*
  • Biological Transport
  • Carrier Proteins / metabolism
  • Cholesterol / metabolism*
  • Cholesterol Ester Transfer Proteins
  • Disease Models, Animal
  • Glycoproteins*
  • Lipase / metabolism
  • Mice
  • Mice, Transgenic
  • Phosphatidylcholine-Sterol O-Acyltransferase / metabolism

Substances

  • Apolipoprotein A-I
  • Carrier Proteins
  • Cholesterol Ester Transfer Proteins
  • Glycoproteins
  • Cholesterol
  • Phosphatidylcholine-Sterol O-Acyltransferase
  • Lipase