The yeast YBR235w gene encodes a homolog of the mammalian electroneutral Na(+)-(K+)-C1- cotransporter family

Biochem Biophys Res Commun. 1995 Dec 5;217(1):150-3. doi: 10.1006/bbrc.1995.2757.

Abstract

The YBR235w gene of the yeast Saccharomyces cerevisiae was found during sequencing of chromosome II. Here, we show that the 1120 aa protein (Ybr235p) encoded by this gene shares strong sequence similarity with the highly related electroneutral Na(+)-C1- and Na(+)-K(+)-C1- cotransporters of animal cells. We hypothesize that this yeast protein also mediates active uptake of C1- into the cell.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Chlorides / metabolism
  • Electrochemistry
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Genes, Fungal*
  • Ion Transport
  • Molecular Sequence Data
  • Multigene Family
  • Potassium / metabolism
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism
  • Sequence Homology, Amino Acid
  • Sodium / metabolism
  • Sodium-Potassium-Chloride Symporters

Substances

  • Carrier Proteins
  • Chlorides
  • Fungal Proteins
  • Sodium-Potassium-Chloride Symporters
  • Sodium
  • Potassium