Abstract
A model of prostate cancer progression based on the expression pattern of informative genes in the human prostate cancer xenograft LuCaP 23.1 is presented. Apparently, there are at least 2 tumor cell populations of LuCaP 23.1, representing 2 different phenotypes. One is NSE (neuron-specific enolase)-positive and the other NSE-negative. NSE-positive tumors were recovered after hormone-independent growth in castrated mice. These hormone-independent tumors also expressed BCL2, a gene product shown to inhibit apoptosis. With NSE, BCL2 and PSA (prostate-specific antigen) as identifying markers, the model specifies a putative progression sequence of the prostate cancer cell types. We also show a proposed lineage relationship among the 3 principal normal cell types found in the prostatic epithelium.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Biomarkers, Tumor
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Cell Differentiation
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DNA Primers / chemistry
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Gene Expression Regulation, Neoplastic
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Humans
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Molecular Sequence Data
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Neoplasm Transplantation
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Orchiectomy
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / pathology*
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-bcl-2
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Proto-Oncogenes
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RNA, Messenger / genetics
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RNA, Neoplasm / genetics
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Transplantation, Heterologous
Substances
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Biomarkers, Tumor
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DNA Primers
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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RNA, Messenger
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RNA, Neoplasm
Associated data
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GENBANK/D90427
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GENBANK/J03460
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GENBANK/J03647
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GENBANK/L19184
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GENBANK/L22473
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GENBANK/M14694
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GENBANK/M14745
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GENBANK/M22349
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GENBANK/M27833
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GENBANK/M31627
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GENBANK/M59040
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GENBANK/M61872
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GENBANK/M63573
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GENBANK/M76125
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GENBANK/M99487
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GENBANK/X07730
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GENBANK/X07979
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GENBANK/X65923
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GENBANK/X67951