Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase

J Med Chem. 1995 Dec 22;38(26):4972-5. doi: 10.1021/jm00026a003.
No abstract available

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • 3',5'-Cyclic-AMP Phosphodiesterases / metabolism
  • Animals
  • Cattle
  • Humans
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Phosphodiesterase Inhibitors / chemical synthesis*
  • Phosphodiesterase Inhibitors / chemistry
  • Phosphodiesterase Inhibitors / pharmacology*
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / chemistry
  • Pyrrolidines / pharmacology*
  • Pyrrolidinones / pharmacology
  • Rolipram
  • Structure-Activity Relationship

Substances

  • GW 3600
  • Phosphodiesterase Inhibitors
  • Pyrrolidines
  • Pyrrolidinones
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Rolipram