Cloning and sequencing of a tpr-met oncogene cDNA isolated from MNNG-transformed human XP fibroblasts

R Wicker; A Bounacer; A Gascon; O Brison; A Sarasin; H G Suárez

doi:10.1016/0167-4781(95)00174-3

Cloning and sequencing of a tpr-met oncogene cDNA isolated from MNNG-transformed human XP fibroblasts

Biochim Biophys Acta. 1995 Dec 27;1264(3):254-6. doi: 10.1016/0167-4781(95)00174-3.

Authors

R Wicker¹, A Bounacer, A Gascon, O Brison, A Sarasin, H G Suárez

Affiliation

¹ C.N.R.S., Institut de Recherches sur le Cancer, Villejuif, France.

PMID: 8547307
DOI: 10.1016/0167-4781(95)00174-3

Abstract

A rearranged tpr-met oncogene was identified in a MNNG-transformed human Xeroderma pigmentosum (XP) cell line (ASKMN). A 2016 bp cDNA was cloned and sequenced, disclosing an ORF with a coding capacity for a 523 aa protein. The sequence of this tpr-met cDNA was very similar to that previously reported in another human MNNG-transformed cell line (MNNG-HOS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Cell Line, Transformed
Cloning, Molecular
DNA, Complementary / biosynthesis
DNA, Complementary / isolation & purification*
Fibroblasts / drug effects
Fibroblasts / metabolism*
Humans
Methylnitronitrosoguanidine*
Molecular Sequence Data
Oncogene Proteins, Fusion / genetics*

Substances

DNA, Complementary
Oncogene Proteins, Fusion
Methylnitronitrosoguanidine

Associated data

GENBANK/U19348