DNA neosynthesis in Auerbach plexus ganglia isolated from the rat hypertrophic gut: an electrophoretic analysis

Int J Dev Neurosci. 1995 Oct;13(6):635-7. doi: 10.1016/0736-5748(95)00035-f.

Abstract

We analysed using electrophoresis the total genomic DNA extracted from isolated Auerbach plexus ganglia of the hypertrophic duodenum upstream from a partial experimental stenosis. Results indicated the presence of two extra-bands migrating below the high molecular weight DNA. suggesting that DNA amplification is the basic mechanism of the DNA neosynthesis previously observed in myenteric neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA / biosynthesis*
  • Diploidy*
  • Electrophoresis
  • Ganglia, Autonomic / metabolism*
  • Genome
  • Hypertrophy
  • In Vitro Techniques
  • Intestinal Mucosa / metabolism*
  • Intestines / innervation
  • Intestines / pathology
  • Male
  • Myenteric Plexus / metabolism*
  • Neurons / metabolism*
  • Rats
  • Rats, Wistar

Substances

  • DNA