Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A

A Inskip; J Elexperu-Camiruaga; N Buxton; P S Dias; J MacIntosh; D Campbell; P W Jones; L Yengi; J A Talbot; R C Strange

doi:10.1042/bj3120713

Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A

Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):713-6. doi: 10.1042/bj3120713.

Authors

A Inskip¹, J Elexperu-Camiruaga, N Buxton, P S Dias, J MacIntosh, D Campbell, P W Jones, L Yengi, J A Talbot, R C Strange, et al.

Affiliation

¹ Department of Neurosurgery, North Staffordshire Hospital, Stoke-on-Trent, Staffordshire, U.K.

Abstract

Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Binding Sites
DNA-Binding Proteins / metabolism
Erythroid-Specific DNA-Binding Factors
Exons
Gene Deletion
Gene Frequency
Genetic Linkage*
Glutathione Transferase / genetics*
Humans
Introns
Molecular Sequence Data
Neoplasms / genetics
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length*
Transcription Factors / metabolism
YY1 Transcription Factor

Substances

DNA-Binding Proteins
Erythroid-Specific DNA-Binding Factors
Transcription Factors
YY1 Transcription Factor
YY1 protein, human
Glutathione Transferase