Abstract
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
MeSH terms
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Acute Disease
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Amino Acid Sequence
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Base Sequence
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Blood Donors
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Blood-Borne Pathogens
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Chronic Disease
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Cloning, Molecular
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Consensus Sequence
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Disease Transmission, Infectious
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Flaviviridae / genetics
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Genome, Viral
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Hepatitis Viruses / chemistry
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Hepatitis Viruses / genetics*
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Hepatitis Viruses / isolation & purification
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Hepatitis, Viral, Human / epidemiology
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Hepatitis, Viral, Human / transmission
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Hepatitis, Viral, Human / virology*
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Humans
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Molecular Sequence Data
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Polymerase Chain Reaction
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RNA Viruses / chemistry
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RNA Viruses / genetics*
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RNA Viruses / isolation & purification
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RNA, Viral / blood
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RNA, Viral / genetics
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Sequence Alignment
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Transfusion Reaction*
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United States / epidemiology
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Viremia / epidemiology
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Viremia / virology
Substances
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RNA, Viral
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Viral Proteins
Associated data
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GENBANK/AB000137
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GENBANK/AB000138
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GENBANK/AB000139
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GENBANK/AB000140
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GENBANK/AB000141
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GENBANK/AB000142
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GENBANK/AB000143
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GENBANK/AB000144
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GENBANK/AB000145
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GENBANK/AB000146
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GENBANK/AB000147
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GENBANK/AB000148
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GENBANK/AB000149
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GENBANK/AB000150
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GENBANK/AB000151
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GENBANK/AB000152
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GENBANK/AB000153
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GENBANK/AB000154
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GENBANK/AB000155
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GENBANK/AB000156
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GENBANK/AB000157
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GENBANK/AB000158
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GENBANK/AB000159
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GENBANK/AB000160
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GENBANK/AB000161
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GENBANK/AB000162
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GENBANK/AB000163