The clinical significance of an autoimmune response against glutamic acid decarboxylase

T M Ellis; M A Atkinson

doi:10.1038/nm0296-148

The clinical significance of an autoimmune response against glutamic acid decarboxylase

Nat Med. 1996 Feb;2(2):148-53. doi: 10.1038/nm0296-148.

Authors

T M Ellis¹, M A Atkinson

Affiliation

¹ University of Florida, Department of Pathology and Laboratory Medicine College of Medicine, Gainesville 32610, USA.

PMID: 8574952
DOI: 10.1038/nm0296-148

Abstract

Glutamic acid decarboxylase is attracting much interest because of its putative involvement in two clinical disorders: stiffman syndrome and insulin-dependent diabetes. Here we discuss the clinical significance of an autoimmune response against GAD and consider how such information may help identify the disease mechanisms of these disorders.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Autoimmunity*
Diabetes Mellitus, Type 1 / etiology
Diabetes Mellitus, Type 1 / immunology*
Glutamate Decarboxylase / immunology*
Humans
Stiff-Person Syndrome / etiology
Stiff-Person Syndrome / immunology*

Substances

Glutamate Decarboxylase