alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase

J Med Chem. 1996 Feb 2;39(3):657-60. doi: 10.1021/jm9507340.
No abstract available

MeSH terms

  • Animals
  • Cholesterol / blood
  • Cricetinae
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology*
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Molecular Conformation
  • Rats
  • Sulfonic Acids / chemistry
  • Sulfonic Acids / pharmacology*

Substances

  • Hypolipidemic Agents
  • Sulfonic Acids
  • Cholesterol
  • Farnesyl-Diphosphate Farnesyltransferase