Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

R M Bertina; P H Reitsma; F R Rosendaal; J P Vandenbroucke

Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

Thromb Haemost. 1995 Jul;74(1):449-53.

Authors

R M Bertina¹, P H Reitsma, F R Rosendaal, J P Vandenbroucke

Affiliation

¹ Hemostasis and Thrombosis Research Center, University Hospital Leiden, The Netherlands.

PMID: 8578504

Abstract

The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.

Publication types

Review

MeSH terms

Adult
Contraceptives, Oral, Hormonal / adverse effects
Disease-Free Survival
Environment
Enzyme Activation
Factor V / genetics*
Factor V Deficiency / complications*
Factor V Deficiency / epidemiology
Factor V Deficiency / genetics
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Partial Thromboplastin Time
Prevalence
Protein C / metabolism*
Risk Factors
Thrombophlebitis / epidemiology
Thrombophlebitis / etiology*

Substances

Contraceptives, Oral, Hormonal
Protein C
factor V Leiden
Factor V