Abstract
Two new series of 1-(1,4-benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes (3,4) were synthesized for evaluation of their pharmacological activities. These compounds showed significant anti-lipid peroxidation (ALP) activities with rat brain homogenate and some of them possessed a protective effect against hypobaric hypoxia in mice.
MeSH terms
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Animals
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Benzoquinones / chemical synthesis*
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Benzoquinones / pharmacology*
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Brain Ischemia / complications
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Brain Ischemia / drug therapy
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Cerebrovascular Circulation / drug effects
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Male
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Mice
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / pharmacology*
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Rats
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Rats, Wistar
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Tetrahydronaphthalenes / chemical synthesis*
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Tetrahydronaphthalenes / pharmacology*
Substances
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Benzoquinones
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Neuroprotective Agents
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Tetrahydronaphthalenes