Abstract
CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology
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Base Sequence
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Cell Death / immunology
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Cell Differentiation / genetics
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Cell Differentiation / immunology
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Cell Separation
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Gene Deletion
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Gene Expression / immunology
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Hodgkin Disease / immunology
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Ki-1 Antigen / genetics
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Ki-1 Antigen / immunology*
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Lymph Nodes / cytology
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Male
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Mice
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Mice, Mutant Strains
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Molecular Sequence Data
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / immunology
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Signal Transduction / immunology
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Superantigens / immunology
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / ultrastructure
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Thymus Gland / cytology
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Thymus Gland / pathology
Substances
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Ki-1 Antigen
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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Superantigens