Abstract
The injection of endothelin-1 (ET-1) (1 pmol/rat) into the dorsolateral periaqueductal gray (PAG) area of freely moving rats induced rotation along the long axis of the body (barrel-rolling). Preinjection (10 min before) of BQ-788 (an ETB receptor selective antagonist; 5 nmol) or bosentan (an ETA/ETB receptor non-selective antagonist; 10 nmol) to the PAG reduced the behavioral response to ET-1. In contrast, pretreatment with FR139317 (an ETA receptor selective antagonist; 5 nmol) did not affect the ET-1-induced barrel-rolling. These results suggest that barrel-rolling induced by microinjection of ET-1 into the PAG area is predominantly mediated via ETB-like receptors.
MeSH terms
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Animals
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Azepines / pharmacology
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Behavior, Animal / drug effects
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Behavior, Animal / physiology*
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Bosentan
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Consciousness
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Endothelin Receptor Antagonists*
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Endothelins / antagonists & inhibitors
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Endothelins / pharmacology*
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Indoles / pharmacology
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Male
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Oligopeptides / pharmacology
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Periaqueductal Gray / drug effects
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Periaqueductal Gray / ultrastructure
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Piperidines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptor, Endothelin A
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Receptor, Endothelin B
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Receptors, Endothelin / physiology*
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Sulfonamides / pharmacology
Substances
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Azepines
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Endothelin Receptor Antagonists
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Endothelins
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Indoles
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Oligopeptides
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Piperidines
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Receptor, Endothelin A
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Receptor, Endothelin B
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Receptors, Endothelin
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Sulfonamides
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FR 139317
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BQ 788
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Bosentan