Quality of Life (QL) following coronary bypass surgery (CABG) can be modified by medical and non-medical factors (i.e., functional class, medical therapy, psychological changes, economic status, educational level, return to work, country origin). The aim of this study was to evaluate QL in 203 patients that underwent CABG (Group A). QL perception was assessed by 5 questionnaires self-rated by the patient. Data obtained by surgical series were compared with 107 patients with coronary artery disease and treated medically (Group B), and a population of 102 normal subjects (Group C). Our findings demonstrated that general well-being, functional status and social participation improved in Group A. Sexual activity decreased in Group A. CABG did not modify job satisfaction. Chest pain was the main variable influencing negatively return to work; age, work before CABG, low educational level and country area were negatively related non medical variables. Work resumption rate decreased significantly in patients over 50 years, in those coming from the south of Italy and also with low educational level.