The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: in vivo and in vitro studies

Psychiatry Clin Neurosci. 1995 Jun;49(3):S247-51. doi: 10.1111/j.1440-1819.1995.tb02192.x.
No abstract available

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / blood
  • Anticonvulsants / pharmacokinetics
  • Cell Division / drug effects
  • Chronic Disease
  • DNA / biosynthesis
  • Female
  • Fibroblasts / drug effects
  • Humans
  • Male
  • Middle Aged
  • Phenytoin / adverse effects
  • Phenytoin / analogs & derivatives*
  • Phenytoin / blood
  • Stereoisomerism

Substances

  • Anticonvulsants
  • 5-(3-hydroxyphenyl)-5-phenylhydantoin
  • Phenytoin
  • DNA