[Radiochemotherapy and simultaneous hormonal therapy of locally advanced prostatic carcinoma]

Strahlenther Onkol. 1996 Apr;172(4):225-8.
[Article in German]

Abstract

Purpose: The results of radiotherapy alone in the prostate cancer stage T3-T4 are not satisfactory. We investigated, whether the combination of radio-chemotherapy with hormone therapy, possible most effective therapy in stage III, will be tolerated without serious side effects.

Patients and methods: Eight patients with prostate cancer T3/T4 were treated with concurrent radio-chemotherapy and hormone therapy. The mean doses in reference point was 61.7 Gy, the single dose was 1.8 Gy. The patients received epirubicin 20 mg/m2 and 5-fluorouracil 800 mg/m2 on day 1 to 5 and 29 to 33 of radiotherapy. The hormone therapy began before the radio-chemotherapy started.

Results: Only the hematological side effects were relevant. Three out of 8 patients had leucopenia grade III and 1 of 8 patients leucopenia grade IV according WHO. Other serious complications could not be observed.

Conclusion: The concurrent radio-chemotherapy with epirubicin and 5-fluorouracil in the combination with hormone therapy was tolerated well. The effectiveness of this new treatment should be examined prospectively in prostate cancer stage T3-T4.

Publication types

  • English Abstract

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / complications
  • Adenocarcinoma / therapy*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Blood Cells / drug effects
  • Blood Cells / radiation effects
  • Carcinosarcoma / blood
  • Carcinosarcoma / complications
  • Carcinosarcoma / therapy*
  • Combined Modality Therapy
  • Hormones / adverse effects
  • Hormones / therapeutic use*
  • Humans
  • Male
  • Neoplasm Staging
  • Orchiectomy
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / complications
  • Prostatic Neoplasms / therapy*
  • Radiotherapy Dosage

Substances

  • Hormones