A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients

MeSH terms

• Adult
• Aged
• Azathioprine / therapeutic use
• Cyclosporine / therapeutic use
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Humans
• Immunosuppressive Agents / adverse effects
• Immunosuppressive Agents / pharmacokinetics*
• Immunosuppressive Agents / therapeutic use*
• Kidney Transplantation / immunology*
• Male
• Middle Aged
• Placebos
• Polyenes / adverse effects
• Polyenes / pharmacokinetics*
• Polyenes / therapeutic use*
• Prednisolone / therapeutic use
• Sirolimus