The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene

M Le Coniat; R Berger

The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene

Ann Genet. 1995;38(4):231-3.

Authors

M Le Coniat¹, R Berger

Affiliation

¹ Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.

PMID: 8629812

Abstract

The gene encoding the proteinase 3. (PRTN3, myeloblastin) was localized to chromosomal band 19p13.3 by radioactive and fluorescent in situ hybridization (FISH) to normal metaphase chromosomes. This localization was shown to be telomeric to the E2A gene by performing FISH to metaphases with balanced translocation t(1;19)((q23;p13) characteristic for a pre-B subtype of acute leukemia. In the unbalanced form of this translocation, a monoallelic loss of the PRTN3 locus was observed with FISH.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Chromosomes, Human, Pair 19*
Humans
In Situ Hybridization, Fluorescence
Myeloblastin
Serine Endopeptidases / genetics*

Substances

Serine Endopeptidases
Myeloblastin