Sequence analysis of the 5' ends of tomato spotted wilt virus N mRNAs

Arch Virol. 1996;141(1):177-84. doi: 10.1007/BF01718599.

Abstract

Messenger RNAs transcribed from the tomato spotted wilt virus (TSWV) RNA genome have characteristic extra non-templated heterogeneous sequences at their 5' ends which may be the result of a cap-snatching event involving cellular mRNAs. In order to investigate the genetic origin of these extra sequences and to gain more insight in the process of cap-snatching as performed by TSWV, nucleocapsid protein (N) mRNAs derived from the TSWV S RNA were cloned and sequenced. Twenty clones were obtained which contained 5'-proximal sequences of non-viral origin, ranging in length from 12 to 21 nucleotides. None of the sequences analyzed were identical and no base preference at the endonucleolytic site was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Capsid / biosynthesis
  • Capsid / genetics*
  • Cloning, Molecular
  • DNA Primers
  • DNA, Complementary
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / chemistry*
  • RNA, Messenger / genetics*
  • RNA, Plant / chemistry
  • Solanum lycopersicum / virology
  • Tospovirus / genetics*
  • Viral Core Proteins / biosynthesis
  • Viral Core Proteins / genetics*

Substances

  • DNA Primers
  • DNA, Complementary
  • RNA, Messenger
  • RNA, Plant
  • Viral Core Proteins