Tumor necrosis factor as marker for monocyte function in chronic myeloid leukemia

V S Chitnis; P M Parikh; J S Nadkarni; V C Kulkarni; S H Advani

doi:10.3109/07357909609012144

Tumor necrosis factor as marker for monocyte function in chronic myeloid leukemia

Cancer Invest. 1996;14(3):231-3. doi: 10.3109/07357909609012144.

Authors

V S Chitnis¹, P M Parikh, J S Nadkarni, V C Kulkarni, S H Advani

Affiliation

¹ Division of Laboratory Medicine, Tata Memorial Hospital, Bombay, India.

PMID: 8630684
DOI: 10.3109/07357909609012144

Abstract

The intactness of monocyte function in chronic myeloid leukemia (CML) patients as assessed by their ability to secret tumor necrosis factor was evaluated. Monocytes from CML patients continued to respond to lipopolysaccharide (LPS) stimulation even during the refractory period, suggesting different pathways for stimulation by LPS and malignant processes.

MeSH terms

Adult
Biomarkers, Tumor / metabolism
Humans
Immunity
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
Lipopolysaccharides / pharmacology
Middle Aged
Monocytes / physiology*
Tumor Necrosis Factor-alpha / metabolism*

Substances

Biomarkers, Tumor
Lipopolysaccharides
Tumor Necrosis Factor-alpha