Synthesis of a glycopeptide carrying a N-linked core pentasaccharide

Bioorg Med Chem. 1995 Nov;3(11):1455-63. doi: 10.1016/0968-0896(95)00139-8.

Abstract

A glycopeptide carrying a pentasaccharide core structure of asparagine-linked glycoproteins was synthesized. The synthesis of the carbohydrate part was performed starting from monosaccharide components in an unambiguous manner. The resultant pentaglycosyl azide was reduced into corresponding glycosyl amine and coupled with an aspartic acid derivative to furnish an Asn-linked oligosaccharide in a protected form. Subsequent coupling with a dipeptide, followed by deprotection gave the target compound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carbohydrate Sequence
  • Glycopeptides / chemical synthesis*
  • Molecular Sequence Data
  • Oligosaccharides

Substances

  • Glycopeptides
  • Oligosaccharides