Abstract
Delayed response to medical treatment sometimes leads to unnecessary liver transplantation in patients with severely decompensated Wilson disease. We report the course of five patients (mean age 13.4 years, range 11 to 15 years) with severely decompensated Wilson disease who were successfully treated medically. Prothrombin time improved after a minimum of 1 month and returned to normal within 3 months to 1 year or more.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Chelation Therapy
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Child
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Copper / urine
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Female
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Hemolysis
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Hepatolenticular Degeneration / drug therapy*
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Hepatolenticular Degeneration / therapy*
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Humans
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Penicillamine / administration & dosage
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Penicillamine / therapeutic use*
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Prothrombin Time
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Sulfates / administration & dosage
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Sulfates / therapeutic use*
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Zinc Compounds / administration & dosage
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Zinc Compounds / therapeutic use*
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Zinc Sulfate
Substances
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Anti-Bacterial Agents
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Sulfates
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Zinc Compounds
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Zinc Sulfate
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Copper
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Penicillamine