Cisplatin-based chemotherapy after retroperitoneal lymph node dissection in patients with pathological stage II nonseminomatous germ cell tumors

J Surg Oncol. 1996 Mar;61(3):195-8. doi: 10.1002/(SICI)1096-9098(199603)61:3<195::AID-JSO6>3.0.CO;2-6.

Abstract

In order to assess the results of cisplatin-based chemotherapy after primary lymph node dissection in patients with pathological stage II nonseminomatous germ cell tumors of the testis, we retrospectively reviewed the long-term outcome of 44 patients who received adjuvant chemotherapy at Institut Gustave Roussy over a 7-year period. Two chemotherapy regimens were sequentially delivered. Twenty-three patients were treated with vinblastine, cyclophosphamide, bleomycin, actinomycin D, and cisplatin (mVAB-6, four cycles), while 21 patients received a combination of etoposide and cisplatin (EP, four cycles). After a median follow-up of 6 years, all patients remain free from progression. The long-term toxicity included retrograde ejaculation in eight patients and severe ototoxicity in two patients. We conclude that four cycles of cisplatin-based chemotherapy for pathological stage II testicular cancer resulted in a 100% cure rate with minimal toxicity.

MeSH terms

  • Adolescent
  • Adult
  • Antibiotics, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Chemotherapy, Adjuvant
  • Cisplatin / administration & dosage*
  • Cisplatin / adverse effects
  • Cyclophosphamide / administration & dosage
  • Dactinomycin / administration & dosage
  • Disease Progression
  • Etoposide / administration & dosage
  • Follow-Up Studies
  • Germinoma / drug therapy
  • Germinoma / surgery*
  • Humans
  • Lymph Node Excision*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Retroperitoneal Space
  • Retrospective Studies
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / surgery*
  • Treatment Outcome
  • Vinblastine / administration & dosage

Substances

  • Antibiotics, Antineoplastic
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Antineoplastic Agents, Phytogenic
  • Bleomycin
  • Dactinomycin
  • Vinblastine
  • Etoposide
  • Cyclophosphamide
  • Cisplatin