Abstract
Adenoviruses may cause severe infections in bone marrow transplant recipients. We report the case of a patient who developed fulminant hepatitis 5 months after bone marrow transplantation. Adenovirus type 2 was cultured from stool and blood samples. The patient died from liver failure. Histologic examination of post-mortem liver samples showed extensive necrosis with nuclear inclusions. Adenovirus was identified in liver cells by electron microscopy and immunohistochemical staining using a monoclonal anti-adenovirus antibody. No other pathogen was identified.
MeSH terms
-
Adenoviridae Infections* / etiology
-
Adenoviridae Infections* / pathology
-
Adenoviruses, Human / classification
-
Adenoviruses, Human / isolation & purification*
-
Adult
-
Bone Marrow Transplantation* / adverse effects
-
Colon / virology
-
Fatal Outcome
-
Hepatic Veno-Occlusive Disease / etiology
-
Hepatic Veno-Occlusive Disease / pathology
-
Hepatitis, Viral, Human / etiology
-
Hepatitis, Viral, Human / pathology
-
Hepatitis, Viral, Human / virology*
-
Humans
-
Hypertension, Portal / etiology
-
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
-
Liver / pathology
-
Liver / virology
-
Lung Diseases, Interstitial / etiology
-
Necrosis
-
Transplantation, Homologous