Abstract
The chromosomal localization of the human endothelin converting enzyme gene (ECE1) has been identified. Southern blot analysis of human genomic DNA from human x mouse somatic cell hybrids demonstrated that ECE1 maps to chromosome 1. Fluorescence in situ hybridization of a digoxigenin-labeled human ECE1 probe to normal human metaphase chromosomes showed that the gene is located within chromosome band 1p36.1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aspartic Acid Endopeptidases / genetics*
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Chromosome Banding
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Chromosome Mapping
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Chromosomes, Human, Pair 1 / genetics*
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Chromosomes, Human, Pair 1 / ultrastructure
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DNA Probes
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Endothelin-Converting Enzymes
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Humans
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Hybrid Cells
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In Situ Hybridization, Fluorescence
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Metalloendopeptidases
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Mice
Substances
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DNA Probes
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Aspartic Acid Endopeptidases
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Metalloendopeptidases
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ECE1 protein, human
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Ece1 protein, mouse
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Endothelin-Converting Enzymes