Abstract
This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Granzymes
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Humans
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Lymphocyte Activation*
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Molecular Sequence Data
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RNA, Messenger / analysis
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Serine Endopeptidases / genetics
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Syphilis / immunology*
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Syphilis / pathology
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T-Lymphocytes, Cytotoxic / immunology*
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Treponema pallidum / immunology
Substances
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RNA, Messenger
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GZMB protein, human
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Granzymes
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Serine Endopeptidases