2-Diazopyrroles: synthesis and antileukemic activity

G Cirrincione; A M Almerico; P Diana; S Grimaudo; P Barraja; G Dattolo; E Aiello; F Mingola

2-Diazopyrroles: synthesis and antileukemic activity

Farmaco. 1996 Apr;51(4):275-7.

Authors

G Cirrincione¹, A M Almerico, P Diana, S Grimaudo, P Barraja, G Dattolo, E Aiello, F Mingola

Affiliation

¹ Istituto Farmacochimico, Università di Palermo, Italy.

PMID: 8645415

Abstract

The title compounds were synthesised in preparative yields by diazotization of the corresponding 2-aminopyrroles. In preliminary screening tests as antileukemic agents they showed modest activity against the murine and human leukemic cell lines FLC and K562S and their multidrug-resistant daunorubicin selected sublines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Humans
Leukemia / drug therapy*
Mice
Pyrroles / chemical synthesis*
Pyrroles / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Pyrroles