Abstract
The antiinflammatory mediators interleukin (IL)-10 and soluble tumor necrosis factor (TNF) receptors p55 (sTNFR-55) and sTNFR-75 in cerebrospinal fluid (CSF) from 37 children with bacterial meningitis were studied. CSF concentrations of IL-10, sTNFR-55, and sTNFR-75 and of the proinflammatory cytokines TNF-alpha, IL-6, and IL-8 were markedly elevated and were, with the exception of the sTNFRs, significantly higher in CSF than in serum. CSF concentrations of sTNFR- 55 and sTNFR-75 were only associated positively with IL-10 levels. CSF glucose levels correlated highly with levels of IL-10, sTNFR-55, and sTNFR-75 and weakly with TNF-alpha and IL-6. Cytokine levels in CSF decreased rapidly, while sTNFR levels remained elevated for at least 24 h.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antigens, CD / analysis*
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Antigens, CD / biosynthesis
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Cefotaxime / therapeutic use
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Ceftazidime / therapeutic use
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Cephalosporins / therapeutic use
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Child
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Child, Preschool
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Cytokines / blood
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Cytokines / cerebrospinal fluid
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Female
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Humans
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Infant
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Interleukin-10 / biosynthesis
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Interleukin-10 / blood
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Interleukin-10 / cerebrospinal fluid*
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Male
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Meningitis, Bacterial / cerebrospinal fluid*
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Meningitis, Bacterial / drug therapy
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Meningitis, Bacterial / immunology
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Receptors, Tumor Necrosis Factor / analysis*
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Receptors, Tumor Necrosis Factor / biosynthesis
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / cerebrospinal fluid
Substances
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Antigens, CD
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Cephalosporins
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Cytokines
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
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Tumor Necrosis Factor-alpha
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Interleukin-10
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Ceftazidime
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Cefotaxime