Abstract
Using different monoclonal antibodies (moAbs) from the 5th International Workshop on Leukocyte Differentiation Antigens we studied the expression of intercellular adhesion molecules (ICAMs) 2 and 3 on a homogeneous group of 23 B cell chronic lymphocytic leukemia (CLL) patients. Our results show that either ICAM-2 or ICAM-3 are constitutively expressed on CD5+ B-CLL cells. Owing to the role of ICAM molecules in governing the migration and traffic of lymphocytes to lymph nodes, our findings need to be validated in a more consistent patient series to understand clinico-prognostic implications of such an expression.
MeSH terms
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Antibodies, Monoclonal / immunology
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Antigens, CD / biosynthesis*
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Antigens, CD / genetics
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Antigens, CD / immunology
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Antigens, Differentiation*
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CD5 Antigens / analysis
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Cell Adhesion Molecules / biosynthesis*
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / immunology
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Cell Movement
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Gene Expression Regulation, Leukemic*
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
Substances
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Antibodies, Monoclonal
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Antigens, CD
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Antigens, Differentiation
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CD5 Antigens
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Cell Adhesion Molecules
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ICAM2 protein, human
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ICAM3 protein, human
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Neoplasm Proteins