McCune-Albright syndrome (MAS) is characterised by the clinical triad precocious puberty, polyostotic bone dysplasia and café-au-lait skin lesions. Some studies have shown the possibility of multiple endocrinological disorders in this condition, especially thyroid disorders. We report the case of three girls with MAS and a heteromultinodular thyroid at sonography, despite the fact that they were clinically and biologically euthyroid. This raises the question of the follow-up and treatment of these lesions.