Abstract
Twenty-nine C-27 steroidal saponins were tested for the inhibitory effects on human spermatozoa in vitro by means of a modified Sander-Cramer method. Twelve of them are responsible for this activity. The structure-activity relationship is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Humans
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Male
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Plants*
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / pharmacology*
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Sperm Motility / drug effects
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Spermatozoa / drug effects*
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Spermatozoa / physiology
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Steroids / chemistry
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Steroids / isolation & purification
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Steroids / pharmacology*
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Structure-Activity Relationship