Abstract
Among 18 patients with primary extragonadal germ cell tumors (8 seminoma and 10 non- seminoma), the disease involved the mediastinum (7), the retroperitoneum (8), multiple lymph nodal sites (2) and the pinealis gland (1). Seventeen patients received cisplatin-based chemotherapy as part of the initial treatment. Fifteen patients (83%) achieved complete remission (6 seminoma and 9 non-seminoma): 12 of them are relapse-free after a median follow-up of 82 months (range 13-138). Five-year overall survival was 65%. No statistically significant survival difference was found between mediastinal and retroperitoneal tumors or patients with seminoma and nonseminoma.
MeSH terms
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Adolescent
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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Brain Neoplasms / drug therapy
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Brain Neoplasms / epidemiology*
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Brain Neoplasms / radiotherapy
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Chemotherapy, Adjuvant
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Disease Progression
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Doxorubicin / administration & dosage
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Etoposide / administration & dosage
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Follow-Up Studies
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Germinoma / drug therapy
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Germinoma / epidemiology*
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Germinoma / therapy
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Humans
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Ifosfamide / administration & dosage
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Life Tables
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Lymph Nodes / pathology*
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Male
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Mediastinal Neoplasms / drug therapy
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Mediastinal Neoplasms / epidemiology*
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Mediastinal Neoplasms / therapy
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Middle Aged
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Pineal Gland* / pathology
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Prognosis
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Remission Induction
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Retroperitoneal Neoplasms / drug therapy
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Retroperitoneal Neoplasms / epidemiology*
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Retroperitoneal Neoplasms / therapy
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Retrospective Studies
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Survival Analysis
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Treatment Outcome
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Vinblastine / administration & dosage
Substances
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Bleomycin
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Vinblastine
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Etoposide
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Doxorubicin
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Cisplatin
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Ifosfamide
Supplementary concepts
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BEP protocol
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ICE protocol 1
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PVA protocol
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PVB protocol