[Recent prognostic factors in vulvar carcinoma: histological, immunohistochemical and flow cytometry studies]

Gynakol Geburtshilfliche Rundsch. 1995:35 Suppl 1:11-4. doi: 10.1159/000272556.
[Article in German]

Abstract

Objectives: Are newer histologic investigations helpful in the evaluation of the prognosis of vulvar carcinoma?

Methods: 147 primary squamous cell carcinomas of the vulva were examined for overall- and disease-free survival (mean observation 59.6 months).

Results: A significance in prognosis was found for FIGO-stage, a new-created histologic grade, p53- and vimentin-expression and amount of T-lymphocytes in tumoral stroma. Unfavourable prognosis was detected for tumors with elevated growth fraction, high proliferating cell-compartment (S + G2 + M) and increased cytokeratin-8-expression.

Conclusions: These investigations are able to describe the malignant potential of a vulvar carcinoma and should therefore influence the decision for a modified radical therapy.

Publication types

  • English Abstract

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology*
  • Cell Division / physiology
  • Disease-Free Survival
  • Female
  • Flow Cytometry*
  • Humans
  • Lymphatic Metastasis
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Survival Rate
  • Vulva / pathology
  • Vulvar Neoplasms / mortality
  • Vulvar Neoplasms / pathology*

Substances

  • Biomarkers, Tumor