Abstract
A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetates / chemistry
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Acetates / isolation & purification*
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Acetates / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Fatty Alcohols / chemistry
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Fatty Alcohols / isolation & purification*
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Fatty Alcohols / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Plant Leaves / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Tumor Cells, Cultured
Substances
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Acetates
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Antineoplastic Agents, Phytogenic
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Fatty Alcohols
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gummiferol