Abstract
Allergic sensitization and the development of effector functions are controlled by IL-4-secreting and IL-5-secreting type 2 T cells. Recent studies have provided new insights into the events triggering the development of type 1 and type 2 T cells, the discrimination of type 1 and type 2 effector T cells from various T-cell subsets, and the improvement of established and new therapeutic strategies, which are aimed at modulating such T-cell functions in the allergic patient.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adjuvants, Immunologic / pharmacology
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Allergens / immunology
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Anti-Inflammatory Agents / pharmacology
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Cytokines / biosynthesis*
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Cytokines / immunology
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Cytokines / metabolism
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Humans
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Hypersensitivity, Immediate / immunology*
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Hypersensitivity, Immediate / therapy
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Immunoglobulin E / biosynthesis
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Immunoglobulin E / immunology
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Interleukin-10 / immunology
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Interleukin-10 / metabolism
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Interleukin-4 / biosynthesis
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Interleukin-4 / immunology
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Interleukin-4 / metabolism
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Models, Immunological
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Steroids
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T-Lymphocyte Subsets / immunology
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Th2 Cells / immunology
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Th2 Cells / metabolism*
Substances
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Adjuvants, Immunologic
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Allergens
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Anti-Inflammatory Agents
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Cytokines
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Steroids
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Interleukin-10
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Interleukin-4
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Immunoglobulin E