Hypopituitarism associated with transient diabetes insipidus followed by an episode of painless thyroiditis in a young man

Intern Med. 1996 Feb;35(2):135-41. doi: 10.2169/internalmedicine.35.135.

Abstract

A 16-year-old male complained of a headache and a high fever followed by polyuria. The endocrinological studies showed he had hypopituitarism and central diabetes insipidus, and magnetic resonance imaging (MRI) revealed a pituitary mass. Diabetes insipidus gradually improved and hydrocortisone treatment was begun at three months after onset, but a month later painless thyroiditis developed. An MRI demonstrated a spontaneous shrinkage of the pituitary mass nine months after onset. Lymphocytic hypophysitis followed by painless thyroiditis was the most probable diagnosis, although it is very uncommon especially among men.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use
  • Contrast Media
  • Diabetes Insipidus / diagnosis
  • Diabetes Insipidus / drug therapy
  • Diabetes Insipidus / etiology*
  • Diagnosis, Differential
  • Gadolinium DTPA
  • Humans
  • Hydrocortisone / therapeutic use
  • Hypopituitarism / diagnosis
  • Hypopituitarism / drug therapy
  • Hypopituitarism / etiology*
  • Inflammation / complications
  • Inflammation / diagnosis
  • Inflammation / drug therapy
  • Lymphocytosis / complications*
  • Lymphocytosis / diagnosis
  • Lymphocytosis / drug therapy
  • Magnetic Resonance Imaging
  • Male
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Pituitary Diseases / complications*
  • Pituitary Diseases / diagnosis
  • Pituitary Diseases / drug therapy
  • Thyroiditis / diagnosis
  • Thyroiditis / drug therapy
  • Thyroiditis / etiology*
  • Tomography, X-Ray Computed

Substances

  • Anti-Inflammatory Agents
  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium DTPA
  • Hydrocortisone