A nonbalanced translocation (10;16) demonstrated by FISH analysis in a case of alveolar adenoma of the lung

Cancer Genet Cytogenet. 1996 Jul 1;89(1):34-7. doi: 10.1016/0165-4608(95)00309-6.

Abstract

Short-term cultures from an alveolar adenoma of the lung were cytogenetically examined. Of the 54 metaphases studied, 44 were characterized by an apparently normal karyotype and 10 showed a pseudodiploid karyotype: 46,XX,add(16)(q24). Fluorescence in situ hybridization studies permitted identification of the add(16)(q24) as a der(16)t(10;16)(q23;q24). This is the first report of a chromosomal aberration in an alveolar adenoma of the lung.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / genetics*
  • Chromosomes, Human, Pair 10*
  • Chromosomes, Human, Pair 16*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Lung Neoplasms / genetics*
  • Middle Aged
  • Pulmonary Alveoli*
  • Translocation, Genetic*