(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist

J Med Chem. 1996 Jun 21;39(13):2435-7. doi: 10.1021/jm960084f.
No abstract available

MeSH terms

  • Animals
  • Antipsychotic Agents / chemical synthesis*
  • Antipsychotic Agents / chemistry
  • Antipsychotic Agents / metabolism
  • Antipsychotic Agents / pharmacology
  • Biological Availability
  • CHO Cells
  • Cricetinae
  • Dopamine Agonists / pharmacology
  • Dopamine Antagonists / chemical synthesis*
  • Dopamine Antagonists / chemistry
  • Dopamine Antagonists / metabolism
  • Dopamine Antagonists / pharmacology
  • Dopamine D2 Receptor Antagonists*
  • Ergolines / antagonists & inhibitors
  • Humans
  • Molecular Structure
  • Piperazines / chemical synthesis*
  • Piperazines / chemistry
  • Piperazines / metabolism
  • Piperazines / pharmacology
  • Protein Binding
  • Quinpirole
  • Receptors, Adrenergic / metabolism
  • Receptors, Dopamine D4
  • Receptors, Serotonin / metabolism
  • Schizophrenia / drug therapy
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry
  • Sulfonamides / metabolism
  • Sulfonamides / pharmacology

Substances

  • Antipsychotic Agents
  • DRD4 protein, human
  • Dopamine Agonists
  • Dopamine Antagonists
  • Dopamine D2 Receptor Antagonists
  • Ergolines
  • Piperazines
  • Receptors, Adrenergic
  • Receptors, Serotonin
  • Sulfonamides
  • Receptors, Dopamine D4
  • Quinpirole
  • sonepiprazole