Abstract
From a human fetal-brain cDNA library we isolated a novel gene encoding a peptide homologous to clathrin-adaptor small chains in rat, mouse, and yeast. The cDNA, designated CLAPS3 (clathrin-associated/assembly/adaptor protein, small 3, 22 kDa), contained an open reading frame of 579 nucleotides encoding 193 amino acids. Northern-blot analysis revealed expression of a 1.35-kb transcript in all human tissues examined. This gene was mapped to chromosome bands 12p13.2 --> p13.1 by FISH.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Protein Complex 3*
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Adaptor Protein Complex alpha Subunits
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Adaptor Protein Complex sigma Subunits
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Adaptor Proteins, Vesicular Transport
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping
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Chromosomes, Human, Pair 12*
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Cloning, Molecular
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DNA
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Gene Expression
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Humans
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Membrane Proteins / genetics
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Molecular Sequence Data
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Nerve Tissue Proteins / genetics*
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Sequence Homology, Amino Acid
Substances
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AP3S1 protein, human
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Adaptor Protein Complex 3
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Adaptor Protein Complex alpha Subunits
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Adaptor Protein Complex sigma Subunits
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Adaptor Proteins, Vesicular Transport
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Ap3s1 protein, mouse
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Membrane Proteins
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Nerve Tissue Proteins
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DNA
Associated data
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GENBANK/D63643
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SWISSPROT/P35181
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SWISSPROT/Q00380
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SWISSPROT/Q00381
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SWISSPROT/Q00382