Ascosteroside, a new antifungal agent from Ascotricha amphitricha. II. Isolation and structure elucidation

J E Leet; S Huang; S E Klohr; K D McBrien

doi:10.7164/antibiotics.49.553

Ascosteroside, a new antifungal agent from Ascotricha amphitricha. II. Isolation and structure elucidation

J Antibiot (Tokyo). 1996 Jun;49(6):553-9. doi: 10.7164/antibiotics.49.553.

Authors

J E Leet¹, S Huang, S E Klohr, K D McBrien

Affiliation

¹ Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.

PMID: 8698638
DOI: 10.7164/antibiotics.49.553

Abstract

The novel antifungal agent ascosteroside (1) was isolated from cultured broth of Ascotricha amphitricha (ATCC 74237). The structure based on spectroscopic data was determined to be an alpha-linked glycoside of a lanostane-type triterpenoid.

MeSH terms

Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification*
Glycosides / chemistry*
Glycosides / isolation & purification*
Magnetic Resonance Spectroscopy
Molecular Structure
Triterpenes / chemistry*
Triterpenes / isolation & purification*
Xylariales

Substances

Antifungal Agents
Glycosides
Triterpenes
ascosteroside