Abstract
A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence. age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Caenorhabditis elegans / enzymology*
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology
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Caenorhabditis elegans Proteins*
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Chromosome Mapping
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Helminth Proteins / genetics
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Helminth Proteins / physiology*
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Longevity / physiology*
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Molecular Sequence Data
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Mutation
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Phosphatidylinositol 3-Kinases
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Phosphatidylinositols / metabolism
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Phosphotransferases (Alcohol Group Acceptor) / genetics
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Phosphotransferases (Alcohol Group Acceptor) / physiology*
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Signal Transduction
Substances
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Caenorhabditis elegans Proteins
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Helminth Proteins
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Phosphatidylinositols
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Phosphatidylinositol 3-Kinases
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Phosphotransferases (Alcohol Group Acceptor)
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AGE-1 protein, C elegans
Associated data
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GENBANK/U56101
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SWISSPROT/P42337