Non-islet-cell tumour induced hypoglycaemia: a case report and review of literature

B C Kuenen; J van Doorn; P H Slee

doi:10.1016/0300-2977(95)00073-9

Non-islet-cell tumour induced hypoglycaemia: a case report and review of literature

Neth J Med. 1996 May;48(5):175-9. doi: 10.1016/0300-2977(95)00073-9.

Authors

B C Kuenen¹, J van Doorn, P H Slee

Affiliation

¹ Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, Netherlands.

PMID: 8710034
DOI: 10.1016/0300-2977(95)00073-9

Abstract

A 54-year-old man presented with a poorly differentiated adenocarcinoma of the rectum with multiple metastases to the liver. During hospitalization the patient developed periods of hypoglycaemia due to production of "big" IGF-II by the tumour. Possible pathophysiological mechanisms of non-islet-cell tumour-induced hypoglycaemia are discussed.

Publication types

Case Reports
Review

MeSH terms

Adenocarcinoma / complications*
Adenocarcinoma / physiopathology
Adenocarcinoma / secondary
Fatal Outcome
Humans
Hypoglycemia / etiology*
Insulin-Like Growth Factor Binding Protein 3 / metabolism
Insulin-Like Growth Factor I / metabolism
Insulin-Like Growth Factor II / metabolism
Liver Neoplasms / complications*
Liver Neoplasms / physiopathology
Liver Neoplasms / secondary
Male
Middle Aged
Rectal Neoplasms / pathology
Rectal Neoplasms / physiopathology

Substances

Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II